![]() It may be caused by barotrauma related to high airway, alveolar, and transpulmonary pressures or by shear forces at lung collapse and opening during tidal breaths. ![]() Ventilator-induced lung injury is an important problem in the acute respiratory distress syndrome (ARDS). An optimal inspiratory pattern allows a reduction of tidal volume and may be part of lung-protective ventilation. In ARDS, CO 2 elimination is importantly enhanced by an inspiratory flow pattern with long MDT and high EIF. Typically, an efficient and a less-efficient pattern of inspiration could result in ± 10% variation of CO 2 elimination, and in individuals, up to 35%. Effects of MDT and EIF were comprehensively described with a simple equation. ResultsĪ long MDT, caused primarily by a long T P, led to importantly enhanced CO 2 elimination. From the single-breath test for CO 2, the volume of CO 2 eliminated by each tidal breath was derived. Patients were ventilated with a computer-controlled ventilator allowing single breaths to be modified with respect to durations of inspiratory flow and postinspiratory pause (T P), as well as the shape of the inspiratory flow wave. In a medical intensive care unit of a university hospital, ARDS patients were studied during sequences of breaths with varying inspiratory flow patterns. The objective was to test the hypothesis that effects of inspiratory gas delivery pattern on CO 2 exchange can be comprehensively described from the effects of MDT and EIF in patients with acute respiratory distress syndrome (ARDS). ![]() In healthy and sick pigs, abrupt cessation of inspiratory flow (that is, high end-inspiratory flow (EIF)), enhances CO 2 elimination. This time is expressed in terms of mean distribution time (MDT), which is the time available for distribution and diffusion of inspired tidal gas within resident alveolar gas. ![]() The inspiratory flow pattern influences CO 2 elimination by affecting the time the tidal volume remains resident in alveoli. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |